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17s-fd-895

Intervention

1 paper2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Federico and Elvia Faggin Foundation and 4 more
  • Animals1

Outcomes

2

Leukemia stem cell maintenance

downin human cells1

1 study

  1. 17s-fd-895 impairs leukemia stem cell maintenance in human cells.

    “treatment with a pharmacologic splicing modulator, 17S-FD-895, reversed pro-survival splice isoform switching and significantly impaired LSC maintenance.”

    Cellspre-clinical patient-derived AML modelsleukemia stem cell

    RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML

    Cell stem cell25 Aug 2016

Pro-survival splice isoform switching

downin human cells1

1 study

  1. 17s-fd-895 decreases pro-survival splice isoform switching in human cells.

    “treatment with a pharmacologic splicing modulator, 17S-FD-895, reversed pro-survival splice isoform switching”

    Cellssplicing reporter assays and pre-clinical patient-derived AML models

    RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML

    Cell stem cell25 Aug 2016

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