RNA splice isoform expression patterns

RNA splice isoform expression patterns are associated with normal versus malignant hematopoietic progenitor cell state in human cells.

“characteristic RNA splice isoform expression patterns that distinguished normal young and aged human stem and progenitor cells (HSPCs) from malignant myelodysplastic syndrome (MDS) and AML progenitors.”

Cellsnormal cells compared with myelodysplastic syndrome and acute myeloid leukemia progenitorshematopoietic stem and progenitor cells

RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML

Cell stem cell·25 Aug 2016