ZFYVE21

2 papers3 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funders: American Federation for Aging Research and 7 more
3 of 3 findings with company ties

Humans1
Animals1

Effects

3

Glomerular EC injury

downin mice1

1 study

ZFYVE21 protects against glomerular EC injury in mice.
“Kidneys from Zfyve21 EC-/- mice showed interstitial edema and glomerular EC injury.”
Animalsknockoutkidney
ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging
Kidney internationalMay 24, 2024

NOS3

upin mice1

1 study

ZFYVE21 activates NOS3 in mice.
“These knockout mice developed accelerated aging phenotypes including reduced endothelial nitric oxide (ENOS) activity, failure to thrive, and kidney insufficiency.”
Animalsknockoutkidney
ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging
Kidney internationalMay 24, 2024

Kidney insufficiency

downin mice1

1 study

ZFYVE21 protects against kidney insufficiency in mice.
“These knockout mice developed accelerated aging phenotypes including reduced endothelial nitric oxide (ENOS) activity, failure to thrive, and kidney insufficiency.”
Animalsknockoutkidney
ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging
Kidney internationalMay 24, 2024

More on Kidney insufficiency

Latest

1 in 12 months

AHA Scientific Sessions 2025 AbstractNov 3

Epigenetic Architecture of Abdominal Aortic Aneurysm and Its Augmented Risk in Smokers: Insights from Methylome-Genome Integration

Cohort study of 40,492 peopleMechanisms

Kidney InternationalMay 27

ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging

Experiments in miceNitric oxide–cGMP signalling