Xrp1
- 2 independent labs in 2 countries
- Funders: Cell Science Research Foundation and 6 more
- Model organisms3
Effects
3Cellular plasticity
upin flies1is required forin flies1
1 study
Cellular plasticity
upin flies1is required forin flies1
Xrp1 induces cellular plasticity in flies.
“Under basal conditions, EE-specific Xrp1 overexpression triggers ectopic expression of progenitor-specific genes, which is necessary for Xrp1 to drive EE plasticity.”
Model organismsEE-specific overexpression under basal conditionsmidgut
Development (Cambridge, England)
Xrp1 is required for cellular plasticity in flies.
“Xrp1 and upd3 are both necessary for radiation-induced EE plasticity.”
Model organismsin radiation-induced EE plasticitymidgut
Development (Cambridge, England)
JNK signaling
upin flies1
1 study
JNK signaling
upin flies1
Xrp1 activates JNK signaling in flies.
“Knockdown of Xrp1 or Irbp18 in U5 snRNP-deficient cells attenuated JNK and p53 activity”
Model organismsknockdown of Xrp1 in U5 snRNP-deficient cells
Xrp1 governs the stress response program to spliceosome dysfunction
Nucleic acids research
Apoptosis
upin flies1
1 study
Apoptosis
upin flies1
Xrp1 increases apoptosis in flies.
“Knockdown of Xrp1 or Irbp18 in U5 snRNP-deficient cells attenuated JNK and p53 activity, restored normal cell cycle progression and growth, and inhibited cell death.”
Model organismsknockdown of Xrp1 in U5 snRNP-deficient cells
Xrp1 governs the stress response program to spliceosome dysfunction
Nucleic acids research
Latest
1 paper in 12 monthsDevelopment
Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut
Experiments in fliesMechanisms
Nucleic Acids Research
Xrp1 governs the stress response program to spliceosome dysfunction
Experiments in fliesDNA damage response
eLife
Shared enhancer gene regulatory networks between wound and oncogenic programs
Experiments in fliesMechanisms