WIPI1
2 papers study it3 findings
- 2 independent labs in 2 countries
- Funders: Academy of Finland and others
- Humans1
- Cells1
Effects
2Autophagy
upin human cells1
1 study
Autophagy
upin human cells1
WIPI1 activates autophagy in human cells.
“increased WIPI1 gene expression enhances the formation of autophagic membranes”
Cellsincreased WIPI1 gene expression
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
Communications biologyAug 24, 2023
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
WIPI1 decreases cellular senescence in human cells.
“Overexpression of several genes from this pathway, CTSB, ATP6V0C, ATG4D, and WIPI1, could promote autophagy and delay senescence in cultured IMR-90 cells”
Cellsshown by overexpressionIMR-90
Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians
Genome researchOct 23, 2018
Upstream
1MYC
downin human cells1
1 study
MYC
downin human cells1
MYC inhibits WIPI1 in human cells.
“MYC binds to the WIPI1 promoter and represses WIPI1 gene expression.”
CellsABL-ERK-MYC signalling
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
Communications biologyAug 24, 2023
Latest
Communications Biology
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
Experiments in human cellsAutophagy
Genome Research
Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians
Cross-sectional study of 76 peopleAutophagy