VCPIP1
- 1 lab in 1 country
- Funders: National Cancer Institute and 1 more
- Cells1
Effects
3Premature aging
downin mice1
1 study
Premature aging
downin mice1
VCPIP1 protects against premature aging in mice.
“Vcpip1 knockout mice are prone to genomic instability and premature aging”
Animalsshown by knockout
Molecular cell9 Jul 2020
Genomic instability
downin mice1
1 study
Genomic instability
downin mice1
VCPIP1 protects against genomic instability in mice.
“Vcpip1 knockout mice are prone to genomic instability and premature aging”
Animalsshown by knockout
Molecular cell9 Jul 2020
SPRTN
upin mouse cells1
1 study
SPRTN
upin mouse cells1
VCPIP1 activates SPRTN in mouse cells.
“VCPIP1, in turn, deubiquitinates SPRTN and promotes its chromatin relocalization”
Cellsin response to DPC induction
Molecular cell9 Jul 2020
Upstream
1ATM
upin mouse cells1
1 study
ATM
upin mouse cells1
ATM activates VCPIP1 in mouse cells.
“the deubiquitinase VCPIP1/VCIP135 is phosphorylated and activated by ATM/ATR”
Cellsin response to DPC induction
Molecular cell9 Jul 2020
Latest
Molecular Cell
Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
Experiments in cellsMechanisms