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Usp45

Gene

1 paper1 finding

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Academia Sinica and 1 more
  • Model organisms1

Effects

1

Autophagy

downin cells1

1 study

  1. Usp45 inhibits autophagy in cells.

    “Loss of dUsp45/USP45 results in autophagy activation and increased levels of V-ATPase to lysosomes, thus enhancing lysosomal acidification and function.”

    Cellsshown by loss of dUsp45/USP45

    The deubiquitinase USP45 inhibits autophagy through actin regulation by Coronin 1B

    The Journal of cell biology11 Mar 2025

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