USP28

There is 1 paper on USP28 in aging research: none in people yet, 1 in cells.

1 paper studies it2 findings

HGNC NCBI Gene Taxon

See all 1 papers on USP28

At a glance

The findings reach cells, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

1 lab in 1 country

Funders: Howard Hughes Medical Institute and 2 more

Cells1

Effects

2

GATA4/NF-κB signaling

upin cells1

1 study

USP28 activates GATA4/NF-κB signaling in cells (replicative senescence).
“USP28 controls activation of both the TP53 branch and the GATA4/NFkB branch that controls the senescence-associated secretory phenotype (SASP).”
Cellsreplicative senescence
Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program
Genes & developmentOct 1, 2017

TP53

upin cells1

1 study

USP28 activates TP53 in cells (replicative senescence).
“USP28 controls activation of both the TP53 branch and the GATA4/NFkB branch that controls the senescence-associated secretory phenotype (SASP).”
Cellsreplicative senescence
Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program
Genes & developmentOct 1, 2017

Latest

Genes & DevelopmentNov 2

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program

Experiments in cellsCellular senescence