USP11
1 of its findings points the other way.
- 2 independent labs in 2 countries
- 1 finding against
- Funders: National Natural Science Foundation of China and 3 more
- Animals3
- Cells1
Effects
3Cellular senescence
downin human cells1upin mice1upin mouse cells1
3 studies
Cellular senescence
downin human cells1upin mice1upin mouse cells1
USP11 increases cellular senescence in mice.
“Both Usp11 knockout and pharmacological inhibition with mitoxantrone (MTX) significantly alleviated UUO-induced p53/p21 pathway activation, tubular senescence and renal fibrosis.”
Animalsshown by Usp11 knockout in UUO mice
Cellular signalling
USP11 decreases cellular senescence in human cells.
“USP11 depletion promotes the induction of senescent cells in a manner dependent on its deubiquitinase activity.”
Cellsshown by USP11 depletion
Biochemical and biophysical research communications
USP11 increases cellular senescence in mouse cells.
“Inhibition or knockdown on Usp11 attenuated Ang-II-induced elevation in Tgfbr2 level, and attenuated the activation of downstream senescent-related signaling pathway and as well as cell senescence.”
Cellsin Ang-II-treated cultured mouse tubular epithelial cells (MTECs)
Acta pharmacologica Sinica
Renal fibrosis
upin mice1
1 study
Renal fibrosis
upin mice1
USP11 increases renal fibrosis in mice.
“Both Usp11 knockout and pharmacological inhibition with mitoxantrone (MTX) significantly alleviated UUO-induced p53/p21 pathway activation, tubular senescence and renal fibrosis.”
Animalsshown by Usp11 knockout in UUO mice
Cellular signalling
Cell cycle regulation
downin human cells1
1 study
Cell cycle regulation
downin human cells1
USP11 inhibits cell cycle regulation in human cells.
“depleting USP11 inhibits cell proliferation and delays cell cycle progression.”
Cellsdepletion of USP11
Biochemical and biophysical research communications