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unc-45

Gene

1 paper2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of General Medical Sciences and 1 more
  • Model organisms1

Effects

2

A-band disorganization

downin worms1

1 study

  1. unc-45 decreases A-band disorganization in worms.

    “Additional expression of UNC-45 results in maintenance of MHC B myosin and suppression of A-band disorganization in old animals.”

    Model organismsadditional expression of UNC-45muscle

    The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging

    Molecular biology of the cell29 May 2024

Sarcopenia

downin worms1

1 study

  1. unc-45 protects against sarcopenia in worms.

    “We observe early onset sarcopenia when UNC-45 is reduced at the beginning of adulthood.”

    Model organismsshown by reduction of UNC-45muscle

    The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging

    Molecular biology of the cell29 May 2024

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