UHRF1
GeneHomo sapiens1 paper2 findingsHGNC 12556NCBI Gene 29128Taxon 9606
- Cells1
Effects
2Epigenetic alterations
downin cells1
1 study
Epigenetic alterations
downin cells1
UHRF1 protects against epigenetic alterations in cells.
Cellsat late-replicating, CpG-sparse genomic regions
A UHRF1 feed-forward mechanism sustains DNA methylation at CpG-sparse genomic regions · bioRxiv · 26 Sep 2026 · Preprint
H3 multi-mono-ubiquitination
is required forin cells1
1 study
H3 multi-mono-ubiquitination
is required forin cells1
UHRF1 is required for H3 multi-mono-ubiquitination in cells.
Cellsvia ubiquitin reading activity of the TTD LGDDSL loop
A UHRF1 feed-forward mechanism sustains DNA methylation at CpG-sparse genomic regions · bioRxiv · 26 Sep 2026 · Preprint
Latest
1A UHRF1 feed-forward mechanism sustains DNA methylation at CpG-sparse genomic regions
Binding of mono-ubiquitinated histone H3 by UHRF1 drives multi-mono-ubiquitination to prevent methylation loss in regions typically degraded during cancer and aging.
bioRxiv · Hrit JA et al.