TRPM6
- 3 independent labs in 2 countries
- Funders: National Center for Advancing Translational Sciences and 8 more
- 2 of 3 findings with company ties
- Humans1
- Animals5
Interventions
1Mallotus japonicus
upin mouse cells1
1 study
Mallotus japonicus
upin mouse cells1
Mallotus japonicus increases TRPM6 in mouse cells.
“M. japonicus leaf extract restored TRPM6 expression and [Mg2+]i, improved mitochondrial function, and suppressed senescence-associated secretory phenotype-related gene expression.”
Cellsin senescent colonic epithelial cells
Archives of biochemistry and biophysicsJun 26, 2026
Associations
2Urinary magnesium excretion
downin mice1
1 study
Urinary magnesium excretion
downin mice1
TRPM6 is associated with urinary magnesium excretion in mice.
“Trpm6 mRNA expression is inversely correlated with the QTL effect”
Animals
Genetic drivers of age-related changes in urinary magnesium excretion
Physiological genomicsJul 22, 2024
Glucose
mixedin humans1
1 study
Glucose
mixedin humans1
TRPM6 is associated with glucose in humans (uncorrected P = 0.03).
“rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose”
Humansuncorrected P = 0.03
The Journal of nutritionJan 23, 2013
Latest
1 in 12 monthsArchives of Biochemistry and Biophysics
Mallotus japonicus leaf extract restores TRPM6 magnesium channel expression and suppresses cellular senescence in colonic epithelial cells
Experiments in miceInterventions
Discovery Medicine
Mechanism of AGT-Mediated Magnesium Ion Uptake in Age-Related Olfactory Dysfunction
Experiments in miceMechanisms
Physiological Genomics
Genetic drivers of age-related changes in urinary magnesium excretion
Experiments in miceMechanisms
Frontiers in Physiology
Ghrelin enhances tubular magnesium absorption in the kidney
Experiments in miceKidney