TMEM106BHABHAPLOTYPE

1. TMEM106BHABHAPLOTYPE increases TMEM106B C-terminal peptide abundance in humans (1.16-fold higher).

   “the risk‐increasing HAB is associated with 1.16‐fold higher abundance”

   Humansrelative to neutral HaB combinationtemporal cortex

   Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration

   AAIC 2025 abstract·24 Dec 2025

2. TMEM106BHABHAPLOTYPE decreases TMEM106B C-terminal peptide abundance in humans (1.1-fold lower).

   “the protective Hab is associated with 1.1‐fold lower TMEM106B C‐terminal peptide abundance”

   Humansrelative to neutral HaB combinationtemporal cortex

   Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration

   AAIC 2025 abstract·24 Dec 2025

More on TMEM106B C-terminal peptide abundance

1. TMEM106BHABHAPLOTYPE raises the risk of Alzheimer's disease in humans.

   “Joint association models revealed that the HAB combination (AluYb8+185‐Threonine) is risk‐increasing”

   Humansjoint association models

   Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration

   AAIC 2025 abstract·24 Dec 2025

More on Alzheimer's disease

1. TMEM106BHABHAPLOTYPE is associated with longevity in humans (OR=1.49, padj=2.18×10‐2).

   “Relative to middle‐aged non‐demented controls, cognitively healthy centenarians were more enriched with Hab (OR=1.49, padj=2.18×10‐2)”

   Humanscognitively healthy centenarians vs middle-aged non-demented controls

   Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration

   AAIC 2025 abstract·24 Dec 2025