TMEM106B C-terminal peptide abundance
1 paper2 findings
- Humans1
Upstream
1TMEM106BHABHAPLOTYPE
upin humans1downin humans1
1 study
TMEM106BHABHAPLOTYPE
upin humans1downin humans1
TMEM106BHABHAPLOTYPE increases TMEM106B C-terminal peptide abundance in humans (1.16-fold higher).
“the risk‐increasing HAB is associated with 1.16‐fold higher abundance”
Humansrelative to neutral HaB combinationtemporal cortex
AAIC 2025 abstract24 Dec 2025
TMEM106BHABHAPLOTYPE decreases TMEM106B C-terminal peptide abundance in humans (1.1-fold lower).
“the protective Hab is associated with 1.1‐fold lower TMEM106B C‐terminal peptide abundance”
Humansrelative to neutral HaB combinationtemporal cortex
AAIC 2025 abstract24 Dec 2025
Latest
1 in 12 monthsAAIC 2025 Abstract
Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration
Case-control study of 5,792 peopleMechanisms