TkR99D
- 1 lab in 1 country
- Funders: Biotechnology and Biological Sciences Research Council and 5 more
- Model organisms3
Effects
2Microbiota-dependent changes in lifespan and triacylglyceride storage
is required forin flies1
1 study
Microbiota-dependent changes in lifespan and triacylglyceride storage
is required forin flies1
TkR99D is required for microbiota-dependent changes in lifespan and triacylglyceride storage in flies.
“These effects require Tk in the midgut, and the cognate TK receptor TkR99D in neurons, implicating a microbiota-gut-neuron relay.”
Model organismsTk-dependent effects of Acetobacter pomorum monoassociationneuronfemales
Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D
eLife22 Dec 2025Preprint
Lifespan shortening
is required forin flies1
1 study
Lifespan shortening
is required forin flies1
TkR99D is required for lifespan shortening in flies.
“These effects require Tk in the midgut, and the cognate TK receptor TkR99D in neurons, implicating a microbiota-gut-neuron relay.”
Model organismsAcetobacter pomorum-mediated effectsneuronfemales
Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D
bioRxiv (Cold Spring Harbor Laboratory)2 Aug 2025Preprint
Latest
2 in 12 monthseLife
Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D
Preprint: experiments in fliesMicrobiome composition
eLife
Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D
Preprint: experiments in fliesMicrobiome composition
bioRxiv
Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D
Preprint: experiments in fliesMicrobiome composition