SYPL2

There is 1 paper on SYPL2 in aging research: none in people yet, 1 in animals. The newest story, Oct 30, 2026: “Loss of a muscle protein mimics age-related changes in mice”.

Gene

1 paper studies it3 findings

HGNCNCBI GeneTaxon

See all 1

None of its findings points the other way.

  • 1 lab in 1 country
  • Funders: National Center for Advancing Translational Sciences and 2 more
  • 3 of 3 findings with company ties
  • Animals1

Effects

3

Cellular homeostasis

downin mice1

1 study
  1. SYPL2 decreases cellular homeostasis in mice (Mg29 knockout or knockdown).

    “Reduced MG29 expression led to decreased muscle fiber cross-sectional area, reduced specific force, blunted SOCE”

    AnimalsMg29 knockout or knockdownskeletal muscle

    Loss of a muscle protein mimics age-related changes in mice

    Biomolecules

More on Cellular homeostasis

Specific force

downin mice1

1 study
  1. SYPL2 decreases specific force in mice (Mg29 knockout or knockdown).

    “Reduced MG29 expression led to decreased muscle fiber cross-sectional area, reduced specific force, blunted SOCE”

    AnimalsMg29 knockout or knockdownskeletal muscle

    Loss of a muscle protein mimics age-related changes in mice

    Biomolecules

Muscle fiber cross-sectional area

downin mice1

1 study
  1. SYPL2 decreases muscle fiber cross-sectional area in mice (Mg29 knockout or knockdown).

    “Reduced MG29 expression led to decreased muscle fiber cross-sectional area, reduced specific force, blunted SOCE”

    AnimalsMg29 knockout or knockdownskeletal muscle

    Loss of a muscle protein mimics age-related changes in mice

    Biomolecules

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 1Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months
Biomolecules

Loss of a muscle protein mimics age-related changes in mice

Experiments in male mice found that losing a muscle membrane protein reduced muscle strength and calcium entry and changed signaling by fat-derived molecules.Experiments in male mice found that losing a muscle membrane protein reduced muscle strength and calcium entry and changed signaling by fat-derived molecules.

Mouse studyMuscle