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SPINT2

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Ajou University and 3 more
  • Cells1

Effects

2

MET

downin human cells1

1 study

  1. SPINT2 inhibits MET in human cells.

    “DNMT1-mediated SPINT2 expression induced c-Met inhibition, triggering senescence.”

    CellsDNMT1-mediated SPINT2 expression

    DNMT1-mediated SPINT2 expression drives early senescence by suppressing c-Met signaling in human fibroblasts

    Aging20 Aug 2025

More on MET

Cellular senescence

upin human cells1

1 study

  1. SPINT2 induces cellular senescence in human cells.

    “Furthermore, SPINT2 overexpression alone induced senescence.”

    Cellsoverexpression

    DNMT1-mediated SPINT2 expression drives early senescence by suppressing c-Met signaling in human fibroblasts

    Aging20 Aug 2025

More on Cellular senescence

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