SOCS2
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Canadian Institutes of Health Research and 2 more
- 1 of 2 findings with company ties
- Humans2
- Animals1
- In silico2
Associations
2Frailty phenotype
mixedin humans1
1 study
Frailty phenotype
mixedin humans1
SOCS2 is associated with frailty phenotype in humans.
“Our study demonstrated the role of genes, PLXCN1 and SOCS2, that contribute to frailty through neurological and immunological pathways.”
Humansimplicated by eQTL analysis
npj aging
GrimAge
upin humans1
1 study
GrimAge
upin humans1
SOCS2 is associated with GrimAge in humans (p = 2.87 × 10−8).
“In addition, we found a novel association signal for SOCS2 rs73218878 (p = 2.87 × 10−8) and accelerated GrimAge.”
Humans
GeroScience
Latest
1 paper in 12 monthsnpj Aging
Ordinal GWAS analysis of the frailty phenotype identified a novel locus at 12q22 that underscores the role of the neurological and immune systems
Genetic association study of 23,105 peopleImmune response
Translational Cancer Research
Construction and validation of senescence risk score signature as a novel biomarker in liver hepatocellular carcinoma: a bioinformatic analysis
Computational studyHepatocellular carcinoma
GeroScience
Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging
Cohort study of 1,000 peopleBiomarkers
Frontiers in Molecular Biosciences
Characterization of cellular senescence patterns predicts the prognosis and therapeutic response of hepatocellular carcinoma
Computational studyHepatocellular carcinoma
Journal of Applied Physiology
Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy
Experiments in ratsMuscle