SNCAIP

1. SNCAIP has no effect on lifespan in mice (nearly two years of age).

   “Sph-1 KO mice survived to nearly two years of age and showed normal body weight, lifespan, motor performance, learning and memory, anxiety-like behavior, attention, and gross brain morphology.”

   Animals

   Synphilin-1 Is Essential for Cytoskeletal Integrity of Brain Ventricular Cilia and Mitochondrial Proteostasis

   International journal of molecular sciences·14 Apr 2026

1. SNCAIP is required for cilium in mice.

   “Together, these findings identify synphilin-1 as a key regulator of microtubule organization and cytoskeletal/organelle homeostasis in ependymal cells, required to maintain motile ciliogenesis”

   Animalsknockout of Sncaipependymal cells

   Synphilin-1 Is Essential for Cytoskeletal Integrity of Brain Ventricular Cilia and Mitochondrial Proteostasis

   International journal of molecular sciences·14 Apr 2026

1. SNCAIP protects against hydrocephalus in mice.

   “revealed early-onset hydrocephalus in Sph-1 KO mice associated with severe loss and disorganization of motile ependymal cilia in the ventricular lining”

   Animalsknockout of Sncaipbrain ventricular lining

   Synphilin-1 Is Essential for Cytoskeletal Integrity of Brain Ventricular Cilia and Mitochondrial Proteostasis

   International journal of molecular sciences·14 Apr 2026

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