SMARCA2

1. SMARCA2 is required for notch signalling in mice.

   “Mechanistically, BRM deficiency compromises Notch signaling at two levels: it reduces the Jag2 ligand pool through persistent depletion of sinusoidal endothelial cells (SECs) and impaired regenerative expansion of Jag2-producing LepR+ stromal cells”

   AnimalsSECs and LepR+ stromal cellsbone marrow

   BRM preserves sinusoidal niche integrity to prevent microenvironmental senescence and sustain hematopoietic stem cells

   bioRxiv·8 Jul 2026Preprint

More on Notch signalling

1. SMARCA2 protects against endothelial degeneration in mice.

   “Following 5-fluorouracil (5-FU)-induced myelosuppression, BrmKO mice exhibit defective sinusoidal regeneration accompanied by endothelial degeneration.”

   Animalsfollowing 5-FU-induced myelosuppression in BrmKO micebone marrow

   BRM preserves sinusoidal niche integrity to prevent microenvironmental senescence and sustain hematopoietic stem cells

   bioRxiv·8 Jul 2026Preprint

1. SMARCA2 prevents myeloid bias in mice.

   “a Brm-deficient microenvironment impairs hematopoietic reconstitution and imposes an aging-like myeloid bias characterized by expansion of granulocyte-monocyte progenitors.”

   Animalsshown by Brm-deficient microenvironmentbone marrow

   BRM preserves sinusoidal niche integrity to prevent microenvironmental senescence and sustain hematopoietic stem cells

   bioRxiv·8 Jul 2026Preprint

1. SMARCA2 improves cellular in mice.

   “Using reciprocal BM transplantation, we demonstrate that a Brm-deficient microenvironment impairs hematopoietic reconstitution and imposes an aging-like myeloid bias characterized by expansion of granulocyte-monocyte progenitors.”

   Animalsshown by Brm-deficient microenvironment impairment in reciprocal BM transplantationbone marrow

   BRM preserves sinusoidal niche integrity to prevent microenvironmental senescence and sustain hematopoietic stem cells

   bioRxiv·8 Jul 2026Preprint