SLFN11

1 paper2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funders: Guizhou Science and Technology Department and 2 more

Cells1

Effects

2

mTOR signalling

downin human cells1

1 study

SLFN11 inhibits mTOR signalling in human cells.
“Mechanistically, SLFN11 bound the RNA helicase DDX1 to attenuate mTOR/eIF4E signaling, thereby resisting senescence.”
CellsSLFN11 overexpressionmesenchymal stem cell
SLFN11 binds DDX1 to counteract human mesenchymal stem/stromal cell senescence through inhibition of mTOR/eIF4E signaling pathway activation
Life sciences6 Jul 2026

More on mTOR signalling

Cellular senescence

downin human cells1

1 study

SLFN11 decreases cellular senescence in human cells.
“SLFN11 overexpression significantly attenuated senescence by reducing DNA damage accumulation, reversing cell cycle arrest, and enhancing proliferation, clonogenicity, and stemness properties.”
Cellsshown by overexpression via lentiviral transductionmesenchymal stem cell
SLFN11 binds DDX1 to counteract human mesenchymal stem/stromal cell senescence through inhibition of mTOR/eIF4E signaling pathway activation
Life sciences6 Jul 2026

More on Cellular senescence

Latest

1 in 12 months

Life Sciences7 Jul

SLFN11 binds DDX1 to counteract human mesenchymal stem/stromal cell senescence through inhibition of mTOR/eIF4E signaling pathway activation

Experiments in human cellsInterventions