SLC13A3
- 1 lab in 1 country
- Funders: National Key Research and Development Program of China and 1 more
- Humans1
- Cells1
Effects
3NAD/NADH ratio
downin human cells1
1 study
NAD/NADH ratio
downin human cells1
SLC13A3 decreases NAD/NADH ratio in human cells.
“The NAD(+)/NADH ratio in WI38/hNaDC3 cells was also decreased.”
Cellsoverexpression of NaDC3 in WI38 cellslung
Mechanisms of ageing and development
SIRT1
downin human cells1
1 study
SIRT1
downin human cells1
SLC13A3 inhibits SIRT1 in human cells.
“Meanwhile, the level of SIRT1 activity was down-regulated.”
Cellsoverexpression of NaDC3embryo lung fibroblasts
Mechanisms of ageing and development
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
SLC13A3 induces cellular senescence in human cells.
“After NaDC3 was overexpressed in two human embryo lung fibroblastic cell lines, WI38 and MRC-5, we found that the cells displayed aging-related phenotypes in advance.”
Cellsoverexpression of NaDC3embryo lung fibroblasts
Mechanisms of ageing and development
Latest
Mechanisms of Ageing and Development
High-affinity Na(+)-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1
Experiments in human cellsSirtuin signaling
The Journals of Gerontology, Series A
Relationship between aging and renal high-affinity sodium-dependent dicarboxylate cotransporter-3 expression characterized with antifusion protein antibody
Cohort study in peopleKidney