SIGLECE

1. SIGLECE protects against oxidative stress and ROS signalling in mice.

   “accelerated aging was related both to an unbalanced ROS metabolism, and to a secondary impairment in detoxification of reactive molecules, ultimately leading to increased damage to cellular DNA, proteins, and lipids”

   Animalsshown by knockout

   Siglec receptors impact mammalian lifespan by modulating oxidative stress

   eLife·7 Apr 2015

More on Oxidative stress and ROS signalling

1. SIGLECE extends lifespan in mice.

   “mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival”

   Animalsshown by knockout

   Siglec receptors impact mammalian lifespan by modulating oxidative stress

   eLife·7 Apr 2015