SHARPIN

1. SHARPIN is associated with hippocampal volume in humans (β=‐0.32, p=2.14x10‐9).

   “locus on chromosome 8 (rs34173062; MAF=0.09), which is a previously reported AD risk variant and eQTL for SHARPIN (β=‐0.22, p = 1.68E‐09), with significant effects in males (β Males =‐0.32, p Males =2.14x10 ‐9 )”

   Humansbrainmalesn = 2,549

   Sex‐specific genetic predictors of hippocampal volume in older adults

   AAIC 2025 abstract·26 Dec 2025

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