SERPINE3

1 paper2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals1

Effects

2

Retinal pigment epithelium

downin mice1

1 study

SERPINE3 protects against retinal pigment epithelium in mice.
“Moreover, loss of SERPINE3 resulted in regional RPE degeneration and increased microglial accumulation in aged mice.”
Animalsloss of SERPINE3 in aged miceretinal pigment epithelium
A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated caspase-1 inhibition
The Journal of clinical investigation7 Jul 2026

Oxidative stress and ROS signalling

downin mouse cells1

1 study

SERPINE3 protects against oxidative stress and ROS signalling in mouse cells.
“Notably, genetic studies indicated that SERPINE3 is essential for the oxidative stress resistance of GFP+ cells.”
Cellsin GFP+ RPE cells under oxidative stressretinal pigment epithelium
A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated caspase-1 inhibition
The Journal of clinical investigation7 Jul 2026

More on Oxidative stress and ROS signalling

Latest

1 in 12 months

The Journal of Clinical Investigation7 Jul

A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated caspase-1 inhibition

Experiments in miceEye