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SDHAF1

Gene

1 paper3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Japan Agency for Medical Research and Development and 6 more
  • Cells1

Interventions

1

Thrombopoietin

upin cells1

1 study

  1. Thrombopoietin increases SDHAF1 in cells.

    “increased succinate dehydrogenase assembly factor 1 (SDHAF1) in old HSCs, induced by physiological low-concentration thrombopoietin (TPO) exposure”

    Cellshematopoietic stem cellphysiological low-concentration

    SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production

    Cell stem cell20 May 2024

More on Thrombopoietin

Effects

2

Hematopoietic stem cell survival

upin cells1

1 study

  1. SDHAF1 increases hematopoietic stem cell survival in cells.

    “(SDHAF1) in old HSCs, induced by physiological low-concentration thrombopoietin (TPO) exposure, enables rapid mitochondrial ATP production upon metabolic stress, thereby improving survival.”

    Cellsupon metabolic stresshematopoietic stem cell

    SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production

    Cell stem cell20 May 2024

Mitochondrial ATP production

upin cells1

1 study

  1. SDHAF1 increases mitochondrial ATP production in cells.

    “increased succinate dehydrogenase assembly factor 1 (SDHAF1) in old HSCs, induced by physiological low-concentration thrombopoietin (TPO) exposure, enables rapid mitochondrial ATP production upon metabolic stress”

    Cellsupon metabolic stresshematopoietic stem cell

    SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production

    Cell stem cell20 May 2024

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