What does the research say about S100A8/S100A9?

S100A8/S100A9

There are 2 papers on S100A8/S100A9 in aging research: 1 observational study in people, 1 in animals. The newest story, Nov 9, 2026: “Cancer survivors with obesity had more cardiovascular disease”.

Gene

2 papers study it2 findings

1 new paper in 30 daysSee all 2 papers on S100A8/S100A9

At a glance

The findings reach people, from one lab or study. 2 independent labs in 1 country.

“S100A8/A9 and NLRP3 co-occurrence was confirmed across 75,132 patients (log2 OR 2.56-2.59; p<0.01).”

Inflammasome Mediated Sex Divergent Cardiovascular Risk and Therapeutic Opportunities in Obese Cancer Survivors: A Multicohort StudyAHA Scientific Sessions 2026 abstract2026doi:10.1161/circ.154.suppl_1.7228

None of its findings points the other way.

2 independent labs in 1 country

Funders: American Heart Association and 2 more

Humans1
Animals1

Effects

Expression in endothelial cells of 18-month-old males

upin mice1

1 study

S100A8/S100A9 increases expression in endothelial cells of 18-month-old males in mice (all five organs; males versus females).
“S100a8 and S100a9, which are calcium binding proteins that are increased in inflammatory and autoimmune states, were upregulated in all organs in males at 18 months”
Animalsall five organs; males versus femalesendothelial cells
Single-Cell Transcriptional Profiling Reveals Sex and Age Diversity of Gene Expression in Mouse Endothelial Cells
Frontiers in geneticsFeb 17, 2021

Associations

NLRP3

upin humans1OR 2.56–2.59

1 study

S100A8/S100A9 is associated with NLRP3 in humans (Genomic co-occurrence analysis) (log2 OR 2.56-2.59).
“S100A8/A9 and NLRP3 co-occurrence was confirmed across 75,132 patients (log2 OR 2.56-2.59; p<0.01).”
HumansGenomic co-occurrence analysisn = 75,132
Cancer survivors with obesity had more cardiovascular disease
AHA Scientific Sessions 2026 abstractNov 2, 2026

Latest

1 paper in 12 months

AHA Scientific Sessions 2026 AbstractNov 9

Cancer survivors with obesity had more cardiovascular disease

Cardiovascular conditions affected 28.2% of cancer survivors with obesity, versus 15.6% of adults with obesity alone, despite lower levels of an inflammation marker.Cardiovascular conditions affected 28.2% of cancer survivors with obesity, versus 15.6% of adults with obesity alone, despite lower levels of an inflammation marker.

Cross-sectional · 325 peopleMechanisms

Paper

Frontiers in GeneticsFeb 17

Single-Cell Transcriptional Profiling Reveals Sex and Age Diversity of Gene Expression in Mouse Endothelial Cells

Experiments in miceMechanisms