rpia-1

1. rpia-1 improves proteostasis in worms.

   “reduce polyglutamine aggregation, and improve the deteriorated body bending rate caused by polyglutamine aggregation”

   Model organismsubiquitous and pan-neuronal knockdown

   Reduced Ribose-5-Phosphate Isomerase A-1 Expression in Specific Neurons and Time Points Promotes Longevity in Caenorhabditis elegans

   Antioxidants (Basel, Switzerland)·Jan 4, 2023

More on Proteostasis

1. rpia-1 decreases oxidative stress and ROS signaling in worms.

   “Ubiquitous and pan-neuronal knockdown of rpia-1 both enhance tolerance to oxidative stress”

   Model organismsubiquitous and pan-neuronal knockdown

   Reduced Ribose-5-Phosphate Isomerase A-1 Expression in Specific Neurons and Time Points Promotes Longevity in Caenorhabditis elegans

   Antioxidants (Basel, Switzerland)·Jan 4, 2023

More on Oxidative stress and ROS signaling

1. rpia-1 extends lifespan in worms.

   “spatially and temporally limited knockdown of rpia-1 prolongs lifespan and improves the healthspan in C. elegans”

   Model organismsspatially and temporally limited knockdown

   Reduced Ribose-5-Phosphate Isomerase A-1 Expression in Specific Neurons and Time Points Promotes Longevity in Caenorhabditis elegans

   Antioxidants (Basel, Switzerland)·Jan 4, 2023