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ref(2)P

Gene

1 paper4 findings

Taxon 7227

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Magyar Tudományos Akadémia and 3 more
  • Model organisms1

Effects

4

Mitochondrial superoxide

downin flies1

1 study

  1. ref(2)P decreases mitochondrial superoxide in flies.

    “reduced levels of aging-associated mitochondrial superoxide.”

    Model organismsin ref(2)P-Atg8a binding mutant flies

    Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses

    Autophagy20 Feb 2022

More on Mitochondrial superoxide

Oxidative stress and ROS signalling

downin flies1

1 study

  1. ref(2)P protects against oxidative stress and ROS signalling in flies.

    “These mutant flies have increased tolerance to oxidative stress and reduced levels of aging-associated mitochondrial superoxide.”

    Model organismsin ref(2)P-Atg8a binding mutant flies

    Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses

    Autophagy20 Feb 2022

More on Oxidative stress and ROS signalling

NRF2–KEAP1 antioxidant response

upin flies1

1 study

  1. ref(2)P activates NRF2–KEAP1 antioxidant response in flies.

    “results in the co-sequestering of Keap1 and thus activates the cnc/NFE2L2/Nrf2 antioxidant pathway.”

    Model organismsin ref(2)P point mutant flies

    Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses

    Autophagy20 Feb 2022

More on NRF2–KEAP1 antioxidant response

Healthspan

no changein flies1

1 study

  1. ref(2)P has no effect on healthspan in flies.

    “has hardly any effect on bulk autophagy, proteasome activity and fly healthspan.”

    Model organismsin ref(2)P point mutant flies

    Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses

    Autophagy20 Feb 2022

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