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PSMD5

Gene

1 paper3 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 3 of 3 findings with company ties
  • Cells1

Effects

2

Ubiquitin–proteasome system

downin flies1downin mice1

1 study

  1. PSMD5 inhibits ubiquitin–proteasome system in flies.

    “S5b/PSMD5 deficiency in Drosophila melanogaster ameliorated the tau rough eye phenotype, enhanced proteasome activity, and extended the life span of tau flies.”

    Model organismsin tau flies

    Role of S5b/PSMD5 in proteasome inhibition caused by TNF-α/NFκB in higher eukaryotes

    Cell reports23 Aug 2012

  2. PSMD5 inhibits ubiquitin–proteasome system in mice.

    “Transgenic mice expressing S5b/PSMD5 exhibited a reduced life span and premature onset of aging-related phenotypes, including reduced proteasome activity in their tissues.”

    Animalsin transgenic mice

    Role of S5b/PSMD5 in proteasome inhibition caused by TNF-α/NFκB in higher eukaryotes

    Cell reports23 Aug 2012

More on Ubiquitin–proteasome system

Lifespan

downin mice1

1 study

  1. PSMD5 shortens lifespan in mice.

    “Transgenic mice expressing S5b/PSMD5 exhibited a reduced life span”

    Animalsin transgenic mice

    Role of S5b/PSMD5 in proteasome inhibition caused by TNF-α/NFκB in higher eukaryotes

    Cell reports23 Aug 2012

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