POM121

1 paper2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funders: Guangzhou Science and Technology Program key projects and 1 more

Animals1

Effects

2

Cellular senescence

downin mice1

1 study

POM121 inhibits cellular senescence in mice.
“Mechanistically, POM121 was found to suppress p53/p21-mediated tubular epithelial cell senescence in AKI.”
Animalsacute kidney injury
Genetic haploinsufficiency of POM121 exacerbates ischemia reperfusion injury induced acute kidney injury by promoting p53/p21-mediated cellular senescence
Tissue & cellJun 25, 2026

More on Cellular senescence

Acute kidney injury

downin mice1

1 study

POM121 protects against acute kidney injury in mice.
“POM121 haploinsufficiency significantly aggravated renal dysfunction and tubular injury after IRI”
Animalsischemia-reperfusion injury
Genetic haploinsufficiency of POM121 exacerbates ischemia reperfusion injury induced acute kidney injury by promoting p53/p21-mediated cellular senescence
Tissue & cellJun 25, 2026

More on Acute kidney injury

Latest

1 in 12 months

Tissue & CellJun 27

Genetic haploinsufficiency of POM121 exacerbates ischemia reperfusion injury induced acute kidney injury by promoting p53/p21-mediated cellular senescence

Experiments in micep53–p21 pathway