Phospholipid composition
mediatesin mice1
PLA2G7 mediates phospholipid composition in mice.
“Lipidomic profiling revealed PLA2G7-dependent remodeling of phospholipid composition, linking NSC-derived lipid metabolism to inhibitory synaptic regulation.”
Animals
Suppressing a stem cell enzyme improved cognition in aging mice
Nature aging14 Oct 2026
Cognitive function
downin mice1
PLA2G7 impairs cognitive function in mice.
“In aged mice, PLA2G7 suppression restored inhibitory circuit function, partially normalized circuit imbalance and improved cognition.”
Animalsshown by PLA2G7 suppression
Suppressing a stem cell enzyme improved cognition in aging mice
Nature aging14 Oct 2026
Inhibitory circuit function
downin mice1
PLA2G7 impairs inhibitory circuit function in mice.
“In aged mice, PLA2G7 suppression restored inhibitory circuit function, partially normalized circuit imbalance and improved cognition.”
Animalsshown by PLA2G7 suppressiondentate gyrus
Suppressing a stem cell enzyme improved cognition in aging mice
Nature aging14 Oct 2026
Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.