pitp-1

1 paper2 findings

NCBI Gene Taxon

1 lab in 1 country

Funders: National Science and Technology Council and 1 more

Model organisms1

Effects

1

mTOR signalling

upin worms1

1 study

pitp-1 activates mTOR signalling in worms.
“Conversely, pitp-1 overexpression shortened lifespan and impaired healthspan via TOR activation.”
Model organismspitp-1 overexpression
Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans
Journal of biomedical science27 Apr 2026

More on mTOR signalling

Upstream

1

daf-16

downin worms1

1 study

daf-16 inhibits pitp-1 in worms.
“pitp-1 was transcriptionally repressed by DAF-16 downstream of insulin/IGF-1 signaling (IIS)”
Model organismsTranscriptional repression downstream of insulin/IGF-1 signaling
Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans
Journal of biomedical science27 Apr 2026

Latest

1 in 12 months

Journal of Biomedical Science28 Apr

Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans

Experiments in wormsmTOR signalling