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pdr-1C169Y

Gene

1 paper studies it6 findings

Taxon

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Association of Pediatric Program Directors and 3 more
  • Model organisms1

Effects

6

Dopaminergic neurodegeneration

no changein worms1

1 study

  1. pdr-1C169Y has no effect on dopaminergic neurodegeneration in worms.

    “Dopaminergic neurodegeneration in aged animals was not enhanced when compared to WT.”

    Model organismspdr-1 C169Y mutant animals compared with wild-typedopaminergic neuron

    The Juvenile Parkinson's Disease Mutation C212Y Impairs Mitochondrial Homeostasis in a Caenorhabditis elegans Model

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mitophagy

downin worms1

1 study

  1. pdr-1C169Y decreases mitophagy in worms.

    “Pan-neuronal analysis revealed decreased mitophagy.”

    Model organismspdr-1 C169Y mutant animalsneuron

    The Juvenile Parkinson's Disease Mutation C212Y Impairs Mitochondrial Homeostasis in a Caenorhabditis elegans Model

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

More on Mitophagy

Mitochondrial membrane potential

upin worms1

1 study

  1. pdr-1C169Y increases mitochondrial membrane potential in worms.

    “Unique mitochondrial phenotypes were observed, including an increased mitochondrial area and mitochondrial membrane potential.”

    Model organismsHomozygous pdr-1 C169Y mutant animals

    The Juvenile Parkinson's Disease Mutation C212Y Impairs Mitochondrial Homeostasis in a Caenorhabditis elegans Model

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

More on Mitochondrial membrane potential

Mitochondrial area

upin worms1

1 study

  1. pdr-1C169Y increases mitochondrial area in worms.

    “Unique mitochondrial phenotypes were observed, including an increased mitochondrial area and mitochondrial membrane potential.”

    Model organismsHomozygous pdr-1 C169Y mutant animals

    The Juvenile Parkinson's Disease Mutation C212Y Impairs Mitochondrial Homeostasis in a Caenorhabditis elegans Model

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

More on Mitochondrial area

Thrashing rate

downin worms1

1 study

  1. pdr-1C169Y decreases thrashing rate in worms.

    “The PDR-1C169Y homozygous mutant animals exhibited a shorter lifespan and decreased thrashing rate compared with wild-type or heterozygous animals.”

    Model organismsHomozygous pdr-1 C169Y mutation compared with wild-type or heterozygous animals

    The Juvenile Parkinson's Disease Mutation C212Y Impairs Mitochondrial Homeostasis in a Caenorhabditis elegans Model

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lifespan

downin worms1

1 study

  1. pdr-1C169Y shortens lifespan in worms.

    “The PDR-1C169Y homozygous mutant animals exhibited a shorter lifespan and decreased thrashing rate compared with wild-type or heterozygous animals.”

    Model organismsHomozygous pdr-1 C169Y mutation compared with wild-type or heterozygous animals

    The Juvenile Parkinson's Disease Mutation C212Y Impairs Mitochondrial Homeostasis in a Caenorhabditis elegans Model

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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