pcyt-1

1. pcyt-1 activates oxidative stress and ROS signaling in worms (reduced PC synthesis / pcyt-1 mutant).

   “only the oxidative stress response is elevated, consistent with increased peroxidation-prone LCPUFAs in the pcyt-1 mutant.”

   Model organismsreduced PC synthesis / pcyt-1 mutant

   Reduced production of a key fat reshapes membranes in worms

   G3 (Bethesda, Md.)·Jul 4, 2026

More on Oxidative stress and ROS signaling

1. pcyt-1 extends lifespan in worms (C211Y variant at standard temperature).

   “P154A is temperature-sensitive, and C211Y causes growth delay, reduced brood size, sterility, and lengthened lifespan at standard temperature.”

   Model organismsC211Y variant at standard temperature

   Reduced production of a key fat reshapes membranes in worms

   G3 (Bethesda, Md.)·Jul 4, 2026

1. pcyt-1 impairs oogenesis in worms (acute PCYT-1 degradation in adults).

   “acute PCYT-1 degradation in adults disrupts oogenesis”

   Model organismsacute PCYT-1 degradation in adults

   A pcyt-1 Allelic Series Reveals In Vivo Consequences of Reduced Phosphatidylcholine Synthesis in C. elegans

   bioRxiv : the preprint server for biology·Apr 25, 2026Preprint

1. pcyt-1 induces developmental arrest in worms (auxin-induced degradation in larvae).

   “Acute auxin-induced degradation of PCYT-1 in larvae causes developmental arrest”

   Model organismsauxin-induced degradation in larvae

   A pcyt-1 Allelic Series Reveals In Vivo Consequences of Reduced Phosphatidylcholine Synthesis in C. elegans

   bioRxiv : the preprint server for biology·Apr 25, 2026Preprint

1. pcyt-1 decreases brood size in worms (C211Y mutation at standard temperature).

   “C211Y causes growth delay, reduced brood size, sterility, and lengthened lifespan at standard temperature.”

   Model organismsC211Y mutation at standard temperature

   A pcyt-1 Allelic Series Reveals In Vivo Consequences of Reduced Phosphatidylcholine Synthesis in C. elegans

   bioRxiv : the preprint server for biology·Apr 25, 2026Preprint