PAWR

PAWR is associated with shared genetic architecture of retinal arteriolar tortuosity and systolic blood pressure in humans (PP.H4 = 0.99; 3/5 credible variants within PAWR).

“PAWR at 12q21 (PP.H4 = 0.99; 3/5 within PAWR)--supported by tissue-matched, moderate eQTL evidence (PP.H4 = 0.71-0.75).”

HumansColocalization at 12q21

Retinal arteriolar tortuosity as a candidate genetic window to inner-ear microvasculature: distributed sharing with blood pressure at CSK and PAWR and a roadmap for larger hearing GWAS

medRxiv·11 Oct 2026Preprint