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NR2E1

Gene

3 papers7 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 3 countries
  • Funders: Deutsche Krebshilfe and 2 more
  • Animals1
  • Cells1
  • In silico1

Effects

5

Cellular senescence

downin human cells1

1 study

  1. NR2E1 prevents cellular senescence in human cells.

    “knocking down its expression, which causes premature senescence in human fibroblasts and epithelial cells.”

    Cellsshown by knockdown

    The nuclear receptor NR2E1/TLX controls senescence

    Oncogene20 Oct 2014

  2. NR2E1 decreases cellular senescence in human cells.

    “In addition NR2E1 expression also counteracts oncogene-induced senescence.”

    Cellsoncogene-induced

    The nuclear receptor NR2E1/TLX controls senescence

    Oncogene20 Oct 2014

  3. NR2E1 inhibits cellular senescence in human cells.

    “Ectopic NR2E1 expression inhibits cellular senescence, extending cellular lifespan in fibroblasts”

    Cellsfibroblast

    The nuclear receptor NR2E1/TLX controls senescence

    Oncogene20 Oct 2014

More on Cellular senescence

Coordination and motor function recovery

upin mice1

1 study

  1. NR2E1 improves coordination and motor function recovery in mice.

    “More newborn mature neurons are formed in Tlx-overexpressing mice, leading to improved coordination and motor function recovery.”

    Animalsstroke; Tlx overexpression

    Tlx Promotes Stroke-Induced Neurogenesis and Neuronal Repair in Young and Aged Mice

    International journal of molecular sciences19 Nov 2024

Newborn mature neuron count

upin mice1

1 study

  1. NR2E1 increases newborn mature neuron count in mice.

    “More newborn mature neurons are formed in Tlx-overexpressing mice, leading to improved coordination and motor function recovery.”

    Animalsstroke; Tlx overexpression

    Tlx Promotes Stroke-Induced Neurogenesis and Neuronal Repair in Young and Aged Mice

    International journal of molecular sciences19 Nov 2024

More on Newborn mature neuron count

neurogenesis

upin mice1

1 study

  1. NR2E1 increases neurogenesis in mice.

    “Tlx overexpression in NSCs leads to massive induction of neurogenesis via stroke.”

    Animalsstroke; Tlx overexpressionneural stem cells

    Tlx Promotes Stroke-Induced Neurogenesis and Neuronal Repair in Young and Aged Mice

    International journal of molecular sciences19 Nov 2024

Lifespan

upin human cells1

1 study

  1. NR2E1 extends lifespan in human cells.

    “extending cellular lifespan in fibroblasts”

    Cellsfibroblast

    The nuclear receptor NR2E1/TLX controls senescence

    Oncogene20 Oct 2014

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