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MIS18A

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of Child Health and Human Development and 1 more
  • Animals1

Effects

2

Fertility

no changein mice1

1 study

  1. MIS18A has no effect on fertility in mice.

    “In addition, there is no detectable detriment to fertility.”

    Animalsoocyte-specific conditional knockout of Mis18α6-8 monthsfemales

    Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly

    Current biology : CB14 Aug 2023

Centromeric CENP-A nucleosome abundance

no changein mice1

1 study

  1. MIS18A has no effect on centromeric CENP-A nucleosome abundance in mice.

    “deletion of Mis18α in the female germ line at the time of birth has no impact on centromeric CENP-A nucleosome abundance, even after 6-8 months of aging”

    Animalsoocyte-specific conditional knockout of Mis18αoocyte6-8 monthsfemales

    Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly

    Current biology : CB14 Aug 2023

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