mir-71

1. mir-71 decreases mitochondrial unfolded protein response in worms.

   “resulting in decreased cell-non-autonomous signaling of mitochondrial stress from muscle to glia cells”

   Model organismsduring severe organelle dysfunction

   The microRNA miR-71 suppresses maladaptive UPRmt signaling through both cell-autonomous and cell-non-autonomous mechanisms

   Nature communications·14 Dec 2025

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1. mir-71 improves locomotion in worms.

   “where it restores sarcomere structure and animal locomotion by directly suppressing the inordinate activation of DVE-1”

   Model organismsduring severe mitochondrial damagemuscle

   The microRNA miR-71 suppresses maladaptive UPRmt signaling through both cell-autonomous and cell-non-autonomous mechanisms

   Nature communications·14 Dec 2025

1. mir-71 inhibits dve-1 in worms.

   “restores sarcomere structure and animal locomotion by directly suppressing the inordinate activation of DVE-1”

   Model organismsduring severe mitochondrial damagemuscle

   The microRNA miR-71 suppresses maladaptive UPRmt signaling through both cell-autonomous and cell-non-autonomous mechanisms

   Nature communications·14 Dec 2025

More on dve-1

1. daf-16 increases mir-71 in worms.

   “miR-71 is induced during severe mitochondrial damage by the combined activities of DAF-16, HIF-1, and ATFS-1”

   Model organismsduring severe mitochondrial damagemuscle

   The microRNA miR-71 suppresses maladaptive UPRmt signaling through both cell-autonomous and cell-non-autonomous mechanisms

   Nature communications·14 Dec 2025

More on daf-16