mir-6-1

1. mir-6-1 inhibits LRP1 in flies.

   “we observed elevated expression of the conserved target gene low-density lipoprotein receptor-related protein 1 (LRP1) in miR-6-inhibited hearts”

   Model organismsin miR-6-inhibited heartsheart

   Mammalian-conserved Drosophila miR-6 regulation of LRP1 in the heart protects against normal cardiac aging

   American journal of physiology. Heart and circulatory physiology·10 Dec 2025

More on LRP1

1. mir-6-1 extends lifespan in flies.

   “heart-specific miR-6 suppression mitigates age-related changes to heart size and function, significantly extends lifespan”

   Model organismsheart-specific miR-6 suppressionheart

   Mammalian-conserved Drosophila miR-6 regulation of LRP1 in the heart protects against normal cardiac aging

   American journal of physiology. Heart and circulatory physiology·10 Dec 2025