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MEG8

Gene

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 4 countries
  • Funders: European Commission and 7 more
  • Animals1
  • Cells1

Effects

4

Apoptosis

upin animals1

1 study

  1. MEG8 activates apoptosis.

    “by activating apoptosis.”

    AnimalsMEG8 overexpression

    MEG8 as an antagonistic pleiotropic mechanism in breast cancer

    Cell death discoveryDec 20, 2024

More on Apoptosis

Cell proliferation

downin animals1

1 study

  1. MEG8 decreases cell proliferation.

    “MEG8 overexpression reduced the proliferative and stemness properties of breast cancer cells both in vitro and in vivo”

    AnimalsMEG8 overexpression

    MEG8 as an antagonistic pleiotropic mechanism in breast cancer

    Cell death discoveryDec 20, 2024

Endothelial barrier function

upin human cells1

1 study

  1. MEG8 improves endothelial barrier function in human cells.

    “The endothelial barrier was also impaired after MEG8 silencing.”

    Cellssilencing in HUVECshuman umbilical vein endothelial cells

    The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing

    Journal of cell scienceMay 26, 2022

Cellular senescence

downin human cells1

1 study

  1. MEG8 protects against cellular senescence in human cells (1.8-fold increase).

    “MEG8 knockdown resulted in a 1.8-fold increase in senescence”

    Cellsknockdown in HUVECshuman umbilical vein endothelial cells

    The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing

    Journal of cell scienceMay 26, 2022

More on Cellular senescence

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