5S rRNA expression

1. Maf1 decreases 5S rRNA expression in flies.

   “Indeed, reducing neuronal Maf1 activity rescues the age-related decline in 5S expression and protein synthesis in the brain of female flies.”

   Model organismsage-related decline, shown by reducing neuronal Maf1 activitybrainfemales

   Loss of Pol III repressor Maf1 in neurons promotes longevity by preventing the age-related decline in 5S rRNA and translation

   PLoS biology·15 Jul 2025

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