Lon

1. Lon decreases unfolded mitochondrial proteins in flies.

   “The translational defect of Lon KD flies was also accompanied by a substantial increase in unfolded mitochondrial proteins.”

   Model organismsshown by Lon knockdown

   Lon protease inactivation in Drosophila causes unfolded protein stress and inhibition of mitochondrial translation

   Cell death discovery·Oct 22, 2018

More on Unfolded mitochondrial proteins

1. Lon increases mitochondrial translation in flies.

   “The respiratory chain defects of Lon knockdown (Lon KD ) flies appeared to result from severely reduced translation of mitochondrially encoded genes.”

   Model organismsshown by Lon knockdown

   Lon protease inactivation in Drosophila causes unfolded protein stress and inhibition of mitochondrial translation

   Cell death discovery·Oct 22, 2018

More on Mitochondrial translation

1. Lon improves respiratory chain function in flies.

   “locomotor impairment, and respiratory defects specific to respiratory chain complexes that contain mitochondrially encoded subunits.”

   Model organismsshown by Lon knockdown; complexes containing mitochondrially encoded subunits

   Lon protease inactivation in Drosophila causes unfolded protein stress and inhibition of mitochondrial translation

   Cell death discovery·Oct 22, 2018

1. Lon protects against early larval lethality in flies.

   “a Lon null allele confers early larval lethality”

   Model organismsshown by a Lon null allele

   Lon protease inactivation in Drosophila causes unfolded protein stress and inhibition of mitochondrial translation

   Cell death discovery·Oct 22, 2018