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lgmn-1

Gene

1 paper1 finding

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 2 countries
  • Funders: National Center for Advancing Translational Sciences and 3 more
  • Animals1

Effects

1

Lifespan

downin worms1

1 study

  1. lgmn-1 shortens lifespan in worms.

    “Overexpression of CEBP-2 or LGMN-1 (AEP) in Caenorhabditis elegans neurons but not muscle stimulates neural excitation and shortens life span.”

    Model organismsneurons

    Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression

    Science advances30 Mar 2022

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