KMT5C

1. KMT5C increases senescence-associated proliferation arrest in human cells (oncogene-induced senescence; elevated SUV420H2/H4K20me3).

   “elevated SUV420H2/H4K20me3 reinforces oncogene-induced senescence-associated proliferation arrest”

   Cellsoncogene-induced senescence; elevated SUV420H2/H4K20me3human cell

   Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability

   Genome biology·Jul 25, 2016

1. KMT5C showed no clear effect on initiation of cellular senescence in human cells (SUV420H2 overexpression).

   “Although elevated SUV420H2 upregulates H4K20me3, this does not accelerate senescence of primary human cells.”

   CellsSUV420H2 overexpressionprimary human cell

   Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability

   Genome biology·Jul 25, 2016

1. MIR29A inhibits KMT5C in mouse cells (downstream of activated TGF-β signaling).

   “both of which directly suppress their novel target, Suv4-20h, thus reducing H4K20me3 abundance in a Smad-dependent manner”

   Cellsdownstream of activated TGF-β signaling

   TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

   Nature communications·Jul 2, 2018

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