KLRC1
- 2 independent labs in 1 country
- Funders: Chinese Academy of Sciences and 6 more
- Humans2
- Animals1
Effects
1Immune response
downin mice1
1 study
Immune response
downin mice1
KLRC1 decreases immune response in mice.
“engage the CD94/natural killer cell receptor group II number A (NKG2A)-Qa-1b checkpoint on T cells, further dampening immunity”
Animalsin aging
CD94/NKG2A-Qa-1b axis as a key modulator of vaccine responsiveness in aging populations
Cell reports4 Nov 2025
Upstream
1XCL2+CD56bright NK cells
upin humans1
1 study
XCL2+CD56bright NK cells
upin humans1
XCL2+CD56bright NK cells increase KLRC1 in humans.
“fetal-derived XCL2+CD56bright NK cells show an upregulation of inhibitory receptor KLRC1”
Humansperipheral blood
Single-cell transcriptional and epigenomic landscape of human blood immune cells across the lifespan
Cell reports11 Mar 2026
Latest
2 in 12 monthsCell Reports
Single-cell transcriptional and epigenomic landscape of human blood immune cells across the lifespan
Cohort study in peopleBlood and immune system
Cell Reports
CD94/NKG2A-Qa-1b axis as a key modulator of vaccine responsiveness in aging populations
Experiments in miceImmune response
International Immunopharmacology
Accelerated T-cell senescence and persistent inflammation in older adults with rheumatoid arthritis
Cross-sectional study of 44 peopleCellular senescence