KLRC1

  • 2 independent labs in 1 country
  • Funders: Chinese Academy of Sciences and 6 more
  • Humans2
  • Animals1

Effects

1

Immune response

downin mice1

1 study
  1. KLRC1 decreases immune response in mice.

    “engage the CD94/natural killer cell receptor group II number A (NKG2A)-Qa-1b checkpoint on T cells, further dampening immunity”

    Animalsin aging

    CD94/NKG2A-Qa-1b axis as a key modulator of vaccine responsiveness in aging populations

    Cell reports4 Nov 2025

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Upstream

1

XCL2+CD56bright NK cells

upin humans1

1 study
  1. XCL2+CD56bright NK cells increase KLRC1 in humans.

    “fetal-derived XCL2+CD56bright NK cells show an upregulation of inhibitory receptor KLRC1”

    Humansperipheral blood

    Single-cell transcriptional and epigenomic landscape of human blood immune cells across the lifespan

    Cell reports11 Mar 2026

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