ITGA1

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funders: Cleveland Clinic and 1 more

Animals2

Effects

Cognitive and social behavioral deficits

upin mice1

1 study

ITGA1 increases cognitive and social behavioral deficits in mice.
“limits glial aging, and mitigates cognitive and social behavioral deficits”
Animalsshown by genetic deletion in lymphatic endothelial cells
Lymphatic CD49a is a driver of meningeal immune aging and cognitive decline
bioRxiv : the preprint server for biology9 Aug 2026Preprint

Dural immune dysfunction

upin mice1

1 study

ITGA1 increases dural immune dysfunction in mice.
“genetic deletion of CD49a in lymphatic endothelial cells broadly reverses age-associated immune dysfunction across dural myeloid, lymphoid and dendritic cell compartments”
Animalsshown by genetic deletion in lymphatic endothelial cells
Lymphatic CD49a is a driver of meningeal immune aging and cognitive decline
bioRxiv : the preprint server for biology9 Aug 2026Preprint

CCL21 release

upin mice1

1 study

ITGA1 activates CCL21 release in mice.
“integrin CD49a is upregulated in aged lymphatic endothelial cells and regulates CCL21 release”
Animalsin lymphatic endothelial cells
Lymphatic CD49a is a driver of meningeal immune aging and cognitive decline
bioRxiv : the preprint server for biology9 Aug 2026Preprint