InR

3 papers3 findings

NCBI Gene 42549 Taxon 7227

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funder: Universidad Nacional Autónoma de México

Animals1
Model organisms2

Effects

2

Glycogen

downin flies1

1 study

InR decreases glycogen in flies.
“these mutant flies, while viable, exhibit hyperactivity and accumulate glycogen and body lipids”
Model organismsshown by hypomorphic mutation
The sole Drosophila melanogaster insulin receptor gene mediates metabolism and movement regulating lipid and carbohydrate stores, sleep, and motor activity
General and comparative endocrinology6 Aug 2026

More on Glycogen

Motor activity

downin flies1

1 study

InR decreases motor activity in flies.
“these mutant flies, while viable, exhibit hyperactivity and accumulate glycogen and body lipids”
Model organismsshown by hypomorphic mutation
The sole Drosophila melanogaster insulin receptor gene mediates metabolism and movement regulating lipid and carbohydrate stores, sleep, and motor activity
General and comparative endocrinology6 Aug 2026

Associations

1

Sleep

mixedin flies1

1 study

InR is associated with sleep in flies.
“The proportion of time spent sleeping is also altered”
Model organismsshown by hypomorphic mutation
The sole Drosophila melanogaster insulin receptor gene mediates metabolism and movement regulating lipid and carbohydrate stores, sleep, and motor activity
General and comparative endocrinology6 Aug 2026

Latest

1 in 12 months

General and Comparative Endocrinology7 Aug

The sole Drosophila melanogaster insulin receptor gene mediates metabolism and movement regulating lipid and carbohydrate stores, sleep, and motor activity

Experiments in fliesLipid and ceramide metabolism

Nature Communications25 Oct

Nutrient-sensing alteration leads to age-associated distortion of intestinal stem cell differentiating direction

Experiments in miceNutrient sensing

Nature Communications7 Apr

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

Experiments in fliesDietary restriction