What does the research say about ifng1?

ifng1

There are 2 papers on ifng1 in aging research: none in people yet, 2 in animals. The newest story, Nov 10, 2026: “Immune signal helps coordinate heart repair in zebrafish”.

Gene

2 papers study it6 findings

NCBI Gene Taxon

1 new paper in 30 daysSee all 2 papers on ifng1

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

1 lab in 1 country

Funders: Institute of Biomedical Sciences, Academia Sinica and 1 more

Animals2

Effects

Cardiomyocyte proliferation

upin zebrafish2

2 studies

ifng1 increases cardiomyocyte proliferation in zebrafish during heart regeneration; shown by loss of ifng1.
“Loss of ifng1 disrupted immune cell dynamics, impaired debris clearance and collagen remodeling, reduced cardiomyocyte (CM) protrusion and proliferation, and delayed scar resolution.”
Animalsduring heart regeneration; shown by loss of ifng1heart
Immune signal helps coordinate heart repair in zebrafish
Cell reportsNov 1, 2026
ifng1 increases cardiomyocyte proliferation in zebrafish (shown by knockout).
“Genetic ablation of ifng1 impairs myocardial regeneration, resulting in reduced CM proliferation and persistent fibrotic scarring.”
Animalsshown by knockoutheart
IFN-γ-Dependent Macrophage Reprogramming Coordinates Inflammatory Resolution and Matrix Remodeling in Heart Regeneration
bioRxivMar 20, 2026Preprint

Scar resolution

upin zebrafish1

1 study

ifng1 improves scar resolution in zebrafish during heart regeneration; shown by loss of ifng1.
“Loss of ifng1 disrupted immune cell dynamics, impaired debris clearance and collagen remodeling, reduced cardiomyocyte (CM) protrusion and proliferation, and delayed scar resolution.”
Animalsduring heart regeneration; shown by loss of ifng1heart
Immune signal helps coordinate heart repair in zebrafish
Cell reportsNov 1, 2026

collagen remodeling

upin zebrafish1

1 study

ifng1 improves collagen remodeling in zebrafish during heart regeneration; shown by loss of ifng1.
“Loss of ifng1 disrupted immune cell dynamics, impaired debris clearance and collagen remodeling”
Animalsduring heart regeneration; shown by loss of ifng1heart
Immune signal helps coordinate heart repair in zebrafish
Cell reportsNov 1, 2026

Extracellular matrix remodeling

upin zebrafish1

1 study

ifng1 activates extracellular matrix remodeling in zebrafish (shown by deficiency).
“Transcriptomic analysis of cardiac macrophages further reveals that IFN-{gamma} deficiency disrupts the transition from an inflammatory state to a reparative, ECM-remodeling phenotype”
Animalsshown by deficiencyheart
IFN-γ-Dependent Macrophage Reprogramming Coordinates Inflammatory Resolution and Matrix Remodeling in Heart Regeneration
bioRxivMar 20, 2026Preprint

Latest

2 papers in 12 months

Cell ReportsNov 10

Immune signal helps coordinate heart repair in zebrafish

Experiments in zebrafish linked interferon-gamma signaling in immune cells to scar remodeling and heart muscle renewal after injury.Experiments in zebrafish linked interferon-gamma signaling in immune cells to scar remodeling and heart muscle renewal after injury.

Fish studyImmune response