histones

1. histones improve division potential in human cells.

   “reducing the speed of RNA polymerase II by overexpressing histone components, to counter age-associated changes in nucleosome positioning, also extended lifespan in flies and the division potential of human cells.”

   Cellsby overexpressing histone components

   Ageing-associated changes in transcriptional elongation influence longevity

   Nature·Apr 12, 2023

1. histones extend lifespan in flies.

   “reducing the speed of RNA polymerase II by overexpressing histone components, to counter age-associated changes in nucleosome positioning, also extended lifespan in flies”

   Model organismsby overexpressing histone components

   Ageing-associated changes in transcriptional elongation influence longevity

   Nature·Apr 12, 2023

1. Cell size decreases histones in cells.

   “histones and other chromatin components are diluted in large cells independently of the growth rate”

   Cells

   Delineation of proteome changes driven by cell size and growth rate

   Frontiers in cell and developmental biology·Sep 5, 2022

1. histones are associated with chronological lifespan in yeast.

   “Many of the same histone amino acids are also critical regulators of chronological lifespan.”

   Review

   Screen time: an unbiased search for histone mutations that affect quiescence and chronological aging

   The FEBS journal·May 15, 2023

1. histones are associated with cell cycle regulation in yeast.

   “multiple histone amino acids, likely affecting nucleosome structure and a wide range of chromatin-associated processes, can promote or inhibit quiescence entry.”

   Review

   Screen time: an unbiased search for histone mutations that affect quiescence and chronological aging

   The FEBS journal·May 15, 2023

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